Journal of Environmental Biology

Protective effects of amlodipine on mitochondrial injury

in ischemic reperfused rat heart

Author Details

Najam Ali Khan

(Corresponding author)

Department of Pharmacology and Clinical Research, College of Pharmacy, IFTM University,

Moradabad - 244 001, India

e-mail: alikhan_najam@yahoo.co.in

Pronobesh Chattopadhyay

Defence Research and Development Organization, Tezpur - 784 001, India

Mohammad Abid

Department of Pharmacology and Clinical Research, College of Pharmacy, IFTM University,

Moradabad - 244 001, India

Abhijeet Pawdey

Division of Animal Surgery, Indian Veterinary Research Institute, Bareilly-243 122, India

Kamal Kishore

Department of Pharmacy, M.J.P. Rohilkhand University, Bareilly - 243 006, India

Arun Kumar Wahi

Faculty of Pharmacy, MIT, Moradabad - 244 001, India

Publication Data

Paper received:

29 September 2010

Revised received:

05 March 2011

Re-revised received:

25 April 2011

Re-re-revised received:

19 May 2011

Accepted:

14 June 2011

Abstract

The most significant finding of the present study was the release of nitric oxide (NO). The effect of amlodipine on NO production associated with ischemic reperfused (IR) injury was investigated in rat heart model. Cardiac tissues from animal groups were processed for biochemical, histopathological and electron microscopic studies. There was a significant increase in myocardial catalase (CAT), superoxide dismutase (SOD) and glutathione (GSH) enzymes in amlodipine treated group (1.37, 10.27, 6.39) when compared to IR injured group (0.81, 6.87, 4.53). Histopathology studies showed amlodipine reduce cardiocyte damage in cardiac injury during the cardiac IR. Transmission electron microscopic (TEM) study confirmed the cardioprotective role of amlodipine against IR induced cardiac injury. On the basis of findings, it is hypothesized that a portion of the beneficial actions of amlodipine may involve the release or action of NO and probably by its antioxidant properties. ?????

Key words

Ischemic-reperfusion injury, Amlodipine, Reactive oxygen species?

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