Journal of Environmental Biology
pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP
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Abstract - Issue Nov 2011, 32 (6) Back
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Cardioprotective effects of Commiphora mukul against isoprenaline-induced cardiotoxicity: A biochemical and
histopathological evaluation Author Details |
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Department of Pharmacology, All India Institute of
Medical Sciences, |
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Department of Pharmacology, All India Institute of
Medical Sciences, |
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Department of Pharmacology, All India Institute of
Medical Sciences, |
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Department of Pharmacology, All India Institute of
Medical Sciences, |
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Division of Plant Physiology, Indian Agricultural
Research Institute, |
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(Corresponding
author) |
Department of Pharmacology, All India Institute
of Medical Sciences, e-mail: dsarya16@hotmail.com |
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Publication Data Paper received: 25 June 2010 Revised received: 02 November 2010 Accepted: 20 November
2010 |
Abstract Commiphora mukul commonly known as Guggul is one of the oldest and commonly consumed herb
for promoting heart and vascular health. Present study was undertaken to
evaluate cardioprotective potential of Commiphora mukul
against isoprenaline-induced myocardial necrosis in
rats. Wistar albino rats were divided
into three main groups: sham (saline only), isoprenaline
control (saline and isoprenaline) and Commiphora mukul treated
(Commiphora mukul
and isoprenaline) groups. Commiphora
mukul was administered in three doses 100, 200
and 400 mg kg-1 p.o. for 30 days. On 29th and 30th
day, the animals of isoprenaline control and Commiphora mukul
pretreatment groups were administered isoprenaline
(85 mg kg-1; s.c.), consecutively at an interval
of 24 hr. Isoprenaline administration produced a
significant (p<0.05) decrease in myocardial antioxidants; superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase
(GSHPx), reduced glutathione (GSH), and myocyte injury marker enzymes creatine-
phosphokinase - MB (CK-MB) and lactate dehydrogenase (LDH) along with enhanced lipid peroxidation; malondialdehyde
(MDA) in heart. Commiphora mukul pretreatment reversed the isoprenaline-induced
oxidative changes in rat myocardium by significant (p<0.05) increase in
SOD, CAT, GSHPx, GSH and reduction of MDA. In
addition to improving myocardial antioxidant status, Commiphora
mukul also prevented the leakage of LDH and
CK-MB from heart. Further, histopathological examination showed the reduction
of necrosis, edema and inflammation following Commiphora
mukul pretreatment. Based on present findings,
it is concluded that Commiphora mukul may be a potential preventive and therapeutic
agent against the oxidative stress associated ischemic heart disease owing to
antioxidant and antiperoxidative activity. ??? Key
words Cardiotoxicity, Guggul, Histopathology, Antioxidant enzymes, Necrosis |
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