Journal of Environmental Biology

Alterations in serum biochemical parameters of patients with

lung cancer exposed to radiotherapy

 

Kultigin Cavusoglu*¹, Sukran Cakir Arica² and Cengiz Kurtman³

¹Department of Biology, Faculty of Science and Art, Giresun University, 28049, Debboy Location, Giresun, Turkey

 

²Department of Biology, Faculty of Science and Art, Kirikkale University, 71100, Kirikkale,Turkey

 

³Department of Radiation Oncology, Faculty of? Medicine, Ankara University, 06010, Ankara,Turkey

(Received: October 29, 2008; Revised received: February 02, 2009; Accepted: March 02, 2009)

 

Abstract: In this study, the alterations in serum biochemical parameters of patients with lung cancer exposed to radiotherapy was investigated. For this aim, the levels of serum gamma glutamyltransferase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin (ALB), bilurubin (BLB), copper (Cu), sodium (Na) and potassium (K) were evaluated before and after radiotherapy. Serum enzyme, protein, Na and K levels were determined using an autoanalyzer. Serum Cu analysis was made with Atomic Absorbtion Spectrophotometre (AAS). Although we found significant increases in levels of GGT, BLB, Cu and K in patients, levels of AST, ALT, ALB and Na in patients showed significant decreases. The levels of serum AST and ALT fairly decreased after radiotherapy. The level of GGT in patients was significant higher than that in the controls before radiotherapy. However, GGT level showed again a distinctly decrease after radiotherapy. There was an inverse relationship among serum BLB, Cu and ALB values. Besides, serum Na levels showed significantly decrease in patients at the end of radiotherapy treatment compared to the controls and before radiotherapy, and K levels increased significantly following radiotherapy. In conclusion, the selected serum parameters are very sensitive and useful biomarkers for the study of the effects of radiotherapy.

Key words: Lung cancer, Enzyme parameters, Gamma radiation, Radiotherapy, Serum elements

Copyright ? 2010 Triveni Enterprises. All rights reserved. No part of the Journal can be reproduced in any form without prior permission. Responsibility regarding the authenticity of the data, and the acceptability of the conclusions enforced or derived, rest completely with the author(s).