Journal of Environmental Biology

Effects of Mangifera indica fruit extract on cognitive deficits in mice

 

 

Sokindra Kumar¹, Kamal Kishore Maheshwari² and Vijender Singh¹

¹Department of Pharmacy, Ram-Eesh Institute of Vocational and Technical Education, 3-Knowledge

Park I, Kasna Road, Greater Noida - 201306, India

²Department of Pharmacy, MJP Rohilkhand University, Bareilly - 243 006 India

(Received: February 27, 2008; Revised received: July28, 2008; Accepted: October 15, 2008)

 

Abstract: Mangos are a source of bioactive compounds with potential health-promoting activity. The present work was undertaken to evaluate the ethanolic extract of Mangifera indica L. fruit on cognitive performances. The models used to study the effect on cognitive performances are step down passive avoidance task and elevated plus maze task in mice. Chronic treatment (7 days) of extract and vitamin C significantly (p < 0.05) reversed the aging and scopolamine induced memory deficits in both paradigms. Preliminary phytochemical screening revealed the presence of free sugars, saponins, tannins, and flavonoids. The results suggest the extract contained pharmacologically active principles that are memory-enhancing in nature.

Key words: Mangifera indica, Cognitive deficits, Vitamin C, Scopolamine, Antioxidants

 

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