Journal of Environmental Biology

Radical scavenging activity of Trianthema triquetra in male albino rats intoxicated with CCl₄

M. Chitra* and K. Nithyanandhi

P.G. Department of Biochemistry, S.T.E.T. Women’s College, Mannargudi-614 001, India

(Received: May 03, 2005 ; Revised received: October 01, 2005;  Accepted: October 27, 2005)

Abstract:  Radical scavenging activity of ethanolic extract of Trianthema triquetra root was investigated against CCl₄ in rats. The rats were treated with T. triquetra (100 mg, 200 mg/kg b.w.) for a period of 7 days. Antihepatotoxic effect was studied by assaying the activities of thiobarbituric acid (TBARS), reduced glutathione (GSH), glutathione peroxidase (GPx),catalase (CAT), super oxide dismutase (SOD) and vitamin C (Vit. C). Lipid peroxidation is evidenced by an increase in the value of TBARS and also a distinct diminution in the level of GSH, Vit. C at 200 mg/kg b.w. The activity of antioxidant enzymes, such as GPx, CAT, SOD and Vit. E is significantly recovered towards an almost normal level in animals coadministrated with T. triquetra. The maximum protection against CCl₄ induced hepatic injury was afforded by the dose of 200 mg/kg b.w. of Trianthema triquetra.

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