JEB logo

Journal of Environmental Biology

pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP
About Journal
    Home
    Obituary: Dr. R. C. Dalela
    Editorial Board
    Reviewer Panel
    Publication Policies
    Guidelines for Editors
    Guidelines for Reviewers
    Abstracting and Indexing
    Subscription and Payments
    Contact Journal
    About Triveni Enterprises
 
Read Journal
    Current Issue
    Journal Archives
 
For Authors
    Guidelines for Authors
    Terms and Conditions
    Author Resources
    Fees and Payments
    Track Paper Status
 

Google Search the Journal web-site:


    Abstract - Issue Apr 2007, 28 (2)                                     Back


paper

Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro

Yasir Hasan Siddique*, Gulshan Ara, Tanveer Beg and Mohammad Afzal

Department of Zoology, Section of Genetics, Faculty of Life Sciences,

Aligarh Muslim University, Aligarh-202 002, India

(Received: April 29, 2005 ; Revised received: August 15, 2005 ; Accepted: October 28, 2005)

Abstract: Antioxidants and plant products are reported to reduce the genotoxic damage of steroids. In our present study, we have tested different dosages of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in the presence of S9 mix. Treatments with nordihydroguaiaretic acid (NDGA) results in the reduction of the genotoxic damage. A significant decrease was observed at all the tested doses of NDGA in sister chromatic exchanges of number of abnormal cells. The results suggest a protective role of NDGA against the genotoxic damage.

Key words: Nordihydroguaiaretic acid, Ethynodiol acetate, Chromosomal aberrations, Sister chromatid exchanges

 

Copyright ? 2007 Triveni Enterprises. All rights reserved. No part of the Journal can be reproduced in any form without prior permission. Responsibility regarding the authenticity of the data, and the acceptability of the conclusions enforced or derived, rest completely with the author(s).