Journal of Environmental Biology

Screening of hepatoprotective effect of a herbal mixture against CCl₄ induced hepatotoxicity in Swiss albino mice

 

A. Arun Sam Lal*¹, P. Balakrishna Murthy² and K. Sadasivan Pillai³

¹R.C.C. Laboratories India Pvt. Ltd., Genome Valley, Shameerpet, Hyderabad - 500 078, India

²International Institute of Biotechnology and Toxicology, (IIBAT), Padappai-601 301, India

³Orchid Chemicals and Pharmaceuticals Ltd., R and D Centre, Old Mahabalipuram Road,

Sholinganallur, Chennai-600 119, India

(Received: May 25, 2005 ; Revised received: July 15, 2005 ; Accepted: August 12, 2006)

Abstract: The hepatoprotective potential of a herbal mixture was evaluated against CCl₄ induced liver injury in Swiss albino mice. Liv 52, a commercially available polyherbal hepatoprotective drug was evaluated for comparison. The potential toxicity of the above herbal hepatoprotective agents was also compared. It was observed that there was a reduction in the enzyme biomarkers (Aspartate and Alanine Transaminase) of liver injury in the herbal mixture treated groups, which was similar to the reduction initiated by Liv 52. An increase in glutathione was observed in the herbal mixture treated groups and it was assumed that the herbal mixture protects the liver by virtue of its antioxidant nature along with high regeneration initiation potential. From the study it is also concluded that the herbal mixture is safer than Liv 52.

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