Journal of Environmental Biology

Cypermethrin induced pathological and biochemical changes

in reproductive organs of female rats

G.K. Sangha*, Kamalpreet Kaur and K.S. Khera

Department of Zoology, College of Basic Science, Punjab Agricultural University, Ludhiana-141 004, India

*Corresponding Author email : sanghagk@hotmail.com

Publication Data

Paper received:

29 December 2010

Revised received:

18 August 2011

Re-revised received:

03 October 2011

Re-re-revised received:

03 January 2012

Accepted:

26 May 2012

Abstract

Cypermethrin, a synthetic pyrethroid, has broad spectrum use in domestic agriculture, and veterinary applications due to its high bioefficacy, enhanced stability and low mammalian toxicity. The present investigation was performed to investigate the sub acute effects of cypermethrin (25EC) in female rats. Cypermethrin (25EC) at a dose of 50mg kg-1?body weight (1/5th?LD50) was orally given to female rats for 4 weeks. Control rats received similar amount of ground nut oil. Significant decrease in ovarian weight (15.4%) was observed after four weeks of cypermethrin administration while the uterine weight (68.2%) and thickness of myometrium increased at 2 and 4 weeks. Cypermethrin caused degenerative changes in ovary as evidenced by increased follicular atresia and decreased concentration of proteins (38%), lipids (20%), phospholipids (18%) and cholesterol (37%). Acid (49.2%) and alkaline phosphatase (41%) activities were increased while lactate dehydrogenase (37.9%) and 3b?HSDH (31.3%) decreased in treated rat ovary. ??

Key words

Cypermethrin, Biomoleclules, Uterus, Albino rats

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