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Journal of Environmental Biology

pISSN: 0254-8704 ; eISSN: 2394-0379 ; CODEN: JEBIDP

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    Abstract - Issue Apr 2007, 28 (2)                                     Back


Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro

Yasir Hasan Siddique*, Gulshan Ara, Tanveer Beg and Mohammad Afzal

Department of Zoology, Section of Genetics, Faculty of Life Sciences,

Aligarh Muslim University, Aligarh-202 002, India

(Received: April 29, 2005 ; Revised received: August 15, 2005 ; Accepted: October 28, 2005)

Abstract: Antioxidants and plant products are reported to reduce the genotoxic damage of steroids. In our present study, we have tested different dosages of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in the presence of S9 mix. Treatments with nordihydroguaiaretic acid (NDGA) results in the reduction of the genotoxic damage. A significant decrease was observed at all the tested doses of NDGA in sister chromatic exchanges of number of abnormal cells. The results suggest a protective role of NDGA against the genotoxic damage.

Key words: Nordihydroguaiaretic acid, Ethynodiol acetate, Chromosomal aberrations, Sister chromatid exchanges


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