Journal of Environmental Biology

Glutathione and associated enzymes in toxic cataractogenesis-Selenite model

 

Joe Prasad Mathew¹, Priya Joseph², V. C. Thomas¹ and Issac Thomas¹

¹Department of Zoology, St. Berchmans? College, Changanacherry ? 686 101, India

²Department of Zoology, Devamatha College, Kuravilangad ? 686 633, India

 

(Received: 7 September, 2004 ; Accepted: 4 December, 2004)

 

Abstract: Glutathione, g-glutamyl cysteine synthetase (g -GCS) and glutathione reductase (GSH-R) activity were determined biochemically in the lens during various stages after subcutaneous administration of sodium selenite in multiple low dosages and single high dosages. The GSH concentration and g-GCS and GSH-R activity declined progressively after the selenite administration. The changes observed were discussed in relation to the possible role of selenite interaction with GSH and the enzymes.

 

Key words: Selenite, Cataract, GSH, g -GCS, GSH-R.

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